Amiloride is the main potassium-sparing diuretic used to treat hypertension and fibrosis, in Italy it is found in Moduretic in combination with hydrochlorothiazide.

Amiloride is a diuretic that is less effective than furosemide, but safer in terms of safety when using didiuretics because it maintains potassium and therefore reduces the risk of muscle cramps and heart problems.For this reason, it is sometimes used instead of or taken together with furosemide.

Positive rates for amiloride are significantly lower than those for furosemide and acetazolamide, so it is assumed that athletes generally prefer the latter.

Chlorothiazide, hydrochlorothiazide

Chlorothiazide and hydrochlorothiazide are thiazide diuretics and act by inhibiting NaCl transport in the tubolodistal. These substances, as a rule, are little used by athletes, as they are found in urine within 5/6 days after taking them, so they are easy to detect in anti-doping tests. They are milder than furosemide, and this is probably why they are used as intended.

Anti-inflammatories

Anti-inflammatory or anti-inflammatory substance – This substance (or specific therapeutic treatment) is able to reduce inflammation. These substances reduce pain and tissue phenomena responsible for the restoration of damaged tissue. In fact, inflammation is a physiological process triggered by the body to restore the full functionality of an organ or tissue damaged by an agent. However, this process, if left unchecked, can lead to a number of harmful effects, beginning with severe pain felt in the inflamed area.

Anti-inflammatory drugs are different classes of substances that have different biochemical actions, composed of damolecules belonging to very different chemical families, but with similar effects: reducing the symptoms of the inflammatory condition.

The use of anti-inflammatory drugs in the sports field is absolutely justified in the treatment of numerous sports-related injuries, especially at the competitive level. However, in some cases, these substances are used not only to treat inflammation and trauma, but also for possible ergogenic actions associated with their intake.

Inflammation

The inflammatory process consists of a number of biochemical events that are activated to repair damaged tissue or damage these external agents. An inflammatory or inflammatory response is achieved through the production of numerous classes of autoid molecules (a substance that generates a response directly on the cell that releases it and / or on neighboring cells), which are responsible for the biochemical modifications of the variation required to activate response processes to external agents. Inflammation is an innate, nonspecific defense mechanism that is a defense reaction after harmful exposure to physical, chemical and biological agents, the ultimate goal of which is to eliminate the original cause of cell or tissue damage.

The elementary phenomena that make up the inflammatory response include vasodilation and increased permeability, which lead to the passage of fluids from the vascular bed to the damaged tissue and infiltration of leukocytes in the affected area. Inflammation, therefore, serves to destroy and limit the harmful agent, but at the same time serves to activate a number of mechanisms that contribute to the restoration or replacement of damaged tissue, as well as to reduce the pain threshold necessary to prevent further exposure to the damaged area. which could damage it more.

Clinically, the main signs of inflammation are: redness, swelling, heat of the inflamed part, pain, functional changes. All local manifestations of increased vascularization and tissue permeability are necessary to restore the damaged area. These events are caused by the local production of prostaglandins, the main eicosanoid produced by arachidonic acid.

The main functions of prostaglandins also include the transmission of pain signals to the brain and modulation of body temperature to the hypothalamus.

Activity of some eicosanoids.

TISSUE Bronchi, blood vessels, platelets, brain Inflammation, even if the reparative process for the body, if not controlled, can lead to negative consequences, such as pain and tissue changes, therefore, in case of inflammation, drugs are often used to alleviate the symptoms of this process. / p>